Recent Advances in the Measurement of Enantiomeric Excesses
نویسندگان
چکیده
The elaboration of an ever increasing number of chiral catalysts or reagents demands fast and sensitive methods to measure enantiomeric excesses of the products. This review discusses the various ways to solve these problems. Mass spectrometry, chromatographic or chiroptical methodologies, fluorescence, liquid crystals, enzymatic methods, and immunoassays, are some of the technologies which may be used. Kinetic resolution is often a convenient and complementary tool for analysing a mixture of enantiomers.
منابع مشابه
Partial transfer of enantioselective chiralities from a-methylated amino acids, known to be of meteoritic origin, into normal amino acids
There is overwhelming evidence that meteorites bring a-methylated amino acids to earth with some L(S) enantiomeric excess. How does that get transferred into normal biological molecules? In this brief account, we show that an a-methylated amino acid, D(R)-a-methylvaline, can react with pyruvate and phenylpyruvate salts in dry mixtures to form alanine and phenylalanine with L enantiomeric excess...
متن کاملMeasurement of Enantiomeric Excess by Kinetic Resolution and Mass Spectrometry**
The powerful nature of combinatorial synthetic methods for the preparation of diverse libraries of small molecules has often made the analysis of such compounds the rate-limiting step in their application.[1] An intriguing target is the discovery of new enantioselective catalytic processes by the testing of large numbers of candidate catalysts.[2] Optimal use of combinatorial synthesis in this ...
متن کاملMeteoritic Amino Acids: Diversity in Compositions Reflects Parent Body Histories
The analysis of amino acids in meteorites dates back over 50 years; however, it is only in recent years that research has expanded beyond investigations of a narrow set of meteorite groups (exemplified by the Murchison meteorite) into meteorites of other types and classes. These new studies have shown a wide diversity in the abundance and distribution of amino acids across carbonaceous chondrit...
متن کاملOptical Chirality Enhancement in Twisted Arrays of Plasmonic Nano-rods
An important property of electromagnetic fields, which arises from the interaction between fields and chiral molecules, is called optical chirality. By enhancing this field property, while maintaining constant input power, we are able to increase absorption of circularly polarized light by chiral molecules of a certain handedness. This enhancement is achieved through the use of achiral plasmoni...
متن کاملChiral polymerization: symmetry breaking and entropy production in closed systems.
We solve numerically a kinetic model of chiral polymerization in systems closed to matter and energy flow, paying special attention to its ability to amplify the small initial enantiomeric excesses due to the internal and unavoidable statistical fluctuations. The reaction steps are assumed to be reversible, implying a thermodynamic constraint among some of the rate constants. Absolute asymmetri...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2002